At the moment, Twelve vaccines against COVID-19 are investigated in Spain and three of them take place in the National Center for Biotechnology of the CSIC. Beyond speculation about whether the country could become a hub production of these immunizers, the news brings hope amid the devastating effects of the pandemic on the health and economy of the Spanish.
An overview of the Covid-19 vaccines being investigated in Spain
Research is focused on the search for second, third and fourth generation vaccines against SARS-CoV-2. They focus not only on improving the formula to generate greater effectiveness, but also on reach new formats, such as patch and intranasal drugs.
Here we bring a little more information about the three of the twelve hopeful vaccines against Covid-19 that are being investigated in Spain, in the CSIc laboratories.
The single-dose vaccine inspired by immunization against smallpox
This experimental vaccine is developed in the Coronavirus Laboratory of the National Center for Biotechnology (CNB-CSIC). Its great particularity is that It is based on the experience of immunization against smallpox.
To produce it, a genetically manipulated attenuated poxvirus is used to incorporate the protein gene Spike (the one with the spicule). Its formula contains a self-amplifying RNA, capable of multiplying by 5,000 within the body, thus promoting a significant immune response.
Animal model tests indicate that the vaccine generates an immunity Very powerful, through the activation of T lymphocytes and the production of neutralizing antibodies. At present, prototypes of intranasal and single dose vaccine.
It should be remembered that smallpox has been the only disease completely eradicated throughout the history of mankind. A viable conquest, nothing more nothing less, than by a massive vaccination campaign.
Injectable, intranasal, or patch vaccine developed at CSIS
Here we have another experimental drug developed by researchers at CSIS. This vaccine is based on a synthetic DNA vehicle that ‘mimics’ the SARS-CoV-2 mechanism. In this way, manages to enter the cell and cause it to synthesize the spike protein that triggers the immune response.
Currently, they are working in three formats simultaneously. An intramuscular formula (injectable), another intradermal (patch) and also an intranasal one.
The vaccine developed thanks to genetic engineering
The group of researchers responsible for its development has been working with coronavirus for more than 30 years. His expertise has made it possible to use advances in genetic engineering to reconstruct SARS-CoV-2 in the laboratory. This allows you to remove certain elements that can cause severe health complications and enhance infections.
As it is not a virus itself, the antigen used in its formula is not capable of spreading. However, it is inoculated by the same routes as the “real” infection, that is, via the nose. With this, the expectation is that it generates a higher protection in mucous membranes than the other vaccines against Covid-19 that are investigated in Spain.